Archives of Oral Biology
Volume 46, Issue 6 , Pages 487-493 , June 2001

The effect of low-dose interleukin-2-based immunotherapy on salivary function and composition in patients with metastatic renal cell carcinoma

  • Rafael M. Nagler

      Affiliations

    • Oral Biochemistry Laboratory, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
    • Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
    • Corresponding Author InformationCorresponding author. Present address: Department of Oral and Maxillofacial Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel. Tel.: +972-6-6442003; fax: +972-6-6541295
  • ,
  • Eliyahu Gez

      Affiliations

    • Department of Oncology, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Rafael Rubinov

      Affiliations

    • Department of Oncology, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Dov Laufer

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Hanna Ben-Aryeh

      Affiliations

    • Oral Biochemistry Laboratory, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Diana Gaitini

      Affiliations

    • Department of Diagnostic Radiology, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Margarita Filatov

      Affiliations

    • Oral Biochemistry Laboratory, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
  • ,
  • Abraham Kuten

      Affiliations

    • Department of Oncology, Rambam Medical Center and Technion-Israel Institute of Technology, Haifa, Israel

,Accepted 30 January 2001.

References 

  1. Baum JB, Costa PT, Izutsu TK. Sodium handling by aging human parotid glands is inconsistent with a two-stage secretion model. Am. J. Phys. 1984;246:35–39
  2. Ben-Aryeh H, Serouya R, Kanter Y, Szargel R, Laufer D. Oral health and salivary composition in diabetic patients. J. Diabetes Complications. 1993;7:57–62
  3. Ben-Aryeh H, Jungerman T, Szargel R, Klein E, Laufer D. Salivary flow-rate and composition in schizophrenic patients on clozapine: subjective reports and laboratory data. Biol. Psychiatry. 1996;39:946–949
  4. Blaise D, Viens P, Olive D, Stoppa AM, Gabert J, Pourreau CN, et al. Recombinant interleukin-2 [rIL-2] after autologous bone marrow transplantation [BMT]: a pilot study in 19 patients. Eur. Cytokine Netw. 1991;2:121–129
  5. Boumba D, Skopouli FN, Moutsopoulos HM. Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjogren's syndrome. Br. J. Rheumatol. 1995;34:222–326
  6. Coll J, Tomas S, Vilella R, Corominas J. Interleukin-2 receptor expression in salivary glands of patients with Sjogren's syndrome. J. Rheumatol. 1995;22:1488–1491
  7. Costello R, Blaise D, Jacquemier J, Monges G, Stoppa AM, Viens P, et al. Induction of cutaneous graft-versus-host like reaction by recombinant IL-2 after autologous bone marrow transplantation. Bone Marrow Transplant. 1995;16:199–200
  8. Devi MA, Das NP. Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. Experimentia. 1994;50:489–492
  9. Fox PC, van der Ven PF, Sonies BC, Weiffenbach JM, Baum BJ. Xerostomia: evaluation of a symptom with increasing significance. J. Am. Dent. Assoc. 1985;110:519–525
  10. Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 1995;13:688–696
  11. Hanninen EL, Kirchner H, Atzpodien J. Interleukin-2 based home therapy of metastatic renal cell carcinoma: risks and benefits in 215 consecutive single institution patients. J. Urol. 1996;155:19–25
  12. Hay DI, Schlesinger DH, Moreno EC. Phosphoprotein inhibitors of calcium phosphate precipitation from human salivary secretions. Inorganic Perspectives of Biological Medicine. 1979;2:271–274
  13. Hofmockel G, Langer W, Theiss WL, Gruss A, Frohmuller HG. Immunochemotherapy for metastatic renal cell carcinoma using a regimen of interleukin-2, interferon-α and 5-fluorouracil. J. Urol. 1996;156:18–21
  14. Katz J, Weiss H, Goldman B, Kanety H, Stannard B, LeRoith D, et al. Cytokines and growth factors modulate cell growth and insulin-like growth factor binding protein secretion by the human salivary cell line [HSG]. J. Cell Physiol. 1995;165:223–227
  15. Klapholz L, Ackerstein A, Goldenhersh MA, Vardy D, Nagler A. Local cutaneous reaction induced by subcutaneous interleukin-2 and interferon alpha-2α immunotherapy following ABMT. Bone Marrow Transplant. 1993;11:443–446
  16. Konno H, Maruo Y, Matin AF, Tanaka T, Nakamura S, Baba S, et al. Effect of liposomal interleukin-2 on ascites-forming rat hepatoma. J. Surg. Oncol. 1992;51:33–37
  17. Lowry OH, Rosebrough NJ, Farr AL, et al.  J. Biol. Chem. 1951;193:265
  18. Mancini G, Carbonara AD, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965;2:235–254
  19. Mandel ID. The role of saliva in maintaining oral homeostasis. J. Am. Dent. Assoc. 1989;119:298–304
  20. Marmary Y, Shiloni E, Katz J. Oral changes in interleukin-2 treated patients: a preliminary report. J. Oral Pathol. Med. 1992;21:230–231
  21. Marmary Y, Okon E, Katz J, Shiloni E. Effect of interleukin-2 on salivary gland morphology and function in mice. Lymphokine Cytokine Res. 1994;13:197–201
  22. Massumoto C, Benyunes MC, Sale G, Beauchamp M, York A, Thompson JA, et al. Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy. Bone Marrow Transplant. 1996;17:351–356
  23. Meehan KR, Verma UN, Rajogopal C, Cahill R, Frankel S, Mazunder A. Stem cell transplantation with chemoradiotherapy myeloablation and interleukin-2. J. Infusional Chemotherapy. 1996;6:28–32
  24. Morecki S, Nagler A, Puyesky Y, Nabet C, Condiotti R, Pick M, et al. Effect of various cytokine combinations on induction of non-MHC-restricted cytotoxicity. Lymphokine Cytokine Res. 1993;12:159–165
  25. Nagler RM, Marmary Y, Krausz Y, Chisin R, Markitziu A, Nagler A. Major salivary gland dysfunction in human acute and chronic graft-versus-host disease. Bone Marrow Transplant. 1996;17:219–224
  26. Nagler RM, Laufer D, Nagler A. Parotoid gland dysfunction in an animal model of chronic graft vs host disease. Arch. Otolaryngol. Head Neck Surg. 1996;122:1057–1060
  27. Nagler A, Ackerstein A, Or R, Naparstek E, Slavin S. Immunotherapy with recombinant human interleukin-2 and recombinant interferon-alpha in lymphoma patients post-autologous marrow or stem cell transplantation. Blood. 1997;89:3951–3959
  28. Nagler A, Nagler R, Ackerstein A, Levi S, Marmary Y. Major salivary gland dysfunction in patients with hematological malignancies receiving interleukin-2-based immunotherapy post-autologous blood stem cell transplantation [ABSCT]. Bone Marrow Transplant. 1997;20:575–580
  29. Nagler RM, Laufer D, Nagler A. Parotid gland dysfunction in a murine model of acute graft versus host disease. Head Neck. 1998;10:58–62
  30. Nagler RM, Nagler A. Pilocarpine hydrochloride relieves xerostomia in chronic graft vs host disease patients: a sialometrical study. Bone Marrow Transplant. 1999;23:1007–1011
  31. Nedwin GE, Svedersky LP, Bringman TS, Palladino MA, Goeddel DV. Effect of interleukin-2, interferon-gamma and mitogens on the production of tumor necrosis factors alpha and beta. J. Immunol. 1985;135:2492–2497
  32. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum. 1996;39:1376–1384
  33. Ramsay AJ, Husband AJ, Ramshaw IA, Bao S, Matthaei KI, Koehler G, et al. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science. 1994;264:561–563
  34. Via CS, Finelman FD. Critical role of interleukin-2 in the development of acute graft-versus-host disease. Int. Immunol. 1993;5:565–572
  35. Walker NI, Gobe GC. Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction. J. Pathol. 1987;153:333–344

PII: S0003-9969(01)00008-5

Archives of Oral Biology
Volume 46, Issue 6 , Pages 487-493 , June 2001