Archives of Oral Biology
Volume 46, Issue 8 , Pages 713-720 , August 2001

An immunoelectron-microscopic study of class II major histocompatibility complex molecule-expressing macrophages and dendritic cells in experimental rat periapical lesions

  • T Kaneko

      Affiliations

    • Pulp Biology and Endodontics, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima-1-chome, Bunkyo-ku, Tokyo 113-8549, Japan
    • Corresponding Author InformationCorresponding author. Fax: +81-3-58035493
    • ,
  • T Okiji

      Affiliations

    • Pulp Biology and Endodontics, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima-1-chome, Bunkyo-ku, Tokyo 113-8549, Japan
    • ,
  • L Kan

      Affiliations

    • Pulp Biology and Endodontics, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima-1-chome, Bunkyo-ku, Tokyo 113-8549, Japan
    • ,
  • H Suda

      Affiliations

    • Pulp Biology and Endodontics, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima-1-chome, Bunkyo-ku, Tokyo 113-8549, Japan
    • ,
  • M Takagi

      Affiliations

    • Molecular Pathology, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima-1-chome, Bunkyo-ku, Tokyo 113-8549, Japan

,Accepted 27 February 2001.

References 

  1. Akamine A, Hashiguchi I, Toriya Y, Maeda K. Immunohistochemical examination on the localization of macrophages and plasma cells in induced rat periapical lesions. Endodon. Dental Traumatol. 1994;10:121–128
  2. Damoiseaux JGMC, Döpp EA, Calame W, Chao D, MacPherson GG, Dijkstra CD. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology. 1994;83:140–147
  3. Dijkstra CD, Damoiseaux JGMC. Macrophage heterogeneity established by immunocytochemistry. Progr. Histochem. Cytochem. 1993;27:1–65
  4. Dijkstra CD, Döpp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology. 1985;54:589–599
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  8. Kaneko, T., Okiji, T., Kan, L., Takagi, M., Suda, H., 2001. Ultrastructural analysis of MHC class II molecule-expressing cells in experimentally-induced periapical lesions in the rat. J. Endodon. In press.
  9. Kawashima N, Okiji T, Kosaka T, Suda H. Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: a quantitative immunohistochemical study. J. Endodon. 1996;22:311–316
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  12. Okiji T, Kawashima N, Kosaka T, Kobayashi C, Suda H. Distribution of Ia antigen-expressing nonlymphoid cells in various stages of induced periapical lesions in rat molars. J. Endodon. 1994;20:27–31
  13. Peters, J.H., Gieseler, R., Thiele, B., Steinbach, F., 1996. Dendritic cells: from ontogenetic orphans to myelomonocytic descendants. Immunol. Today 17, 273–278.
  14. Stashenko P, Teles R, D'Souza R. Periapical inflammatory responses and their modulation. Crit. Rev. Oral Biol. Med. 1998;9:498–521
  15. Stashenko P, Wang C-Y, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg. Oral Med. Oral Pathol. 1994;78:494–502
  16. Steinman RM. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 1991;9:271–296
  17. Suzuki N, Okiji T, Suda H. Enhanced expression of activation-associated molecules on macrophages of heterogeneous populations in expanding periapical lesions in rat molars. Arch. Oral Biol. 1999;44:67–79
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  19. Tani-Ishii N, Wang C-Y, Stashenko P. Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol. Immunol. 1995;10:213–219
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PII: S0003-9969(01)00031-0

doi: 10.1016/S0003-9969(01)00031-0

Archives of Oral Biology
Volume 46, Issue 8 , Pages 713-720 , August 2001

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