Archives of Oral Biology
Volume 46, Issue 8 , Pages 679-688 , August 2001

Isolation and characterization of fibroblasts derived from regenerating human periodontal defects

,Accepted 27 February 2001.

References 

  1. Amar S, Chung KM, Nam SH, Karatzas S, Myokai F, Van Dyke TE. Markers of bone and cementum formation accumulate in tissues regenerated in periodontal defects treated with expanded polytetrafluoroethylene membranes. J. Periodontal Res. 1997;32:148–158
  2. Amar S, Petrungaro P, Amar A, Van Dyke TE. Immunolocalization of bone matrix macromolecules in human tissues regenerated from periodontal defects treated with expanded polytetrafluoroethylene membranes. Arch. Oral Biol. 1995;40:653–661
  3. Asundi VK, Dreher KL. Molecular characterization of vascular smooth muscle decorin: deduced core protein structure and regulation of gene expression. Eur. J. Cell Biol. 1992;59:314–321
  4. Bartold PM, Narayanan AS, Page RC. Platelet-derived growth factor reduces the inhibitory effects of lipopolysaccharide on gingival fibroblast proliferation. J. Periodontal Res. 1992;27:499–505
  5. Bartold PM, Raben A. Growth factor modulation of fibroblasts in simulated wound healing. J. Periodontal Res. 1996;31:205–216
  6. Caffesse RG, Quinones CR. Polypeptide growth factors and attachment proteins in periodontal wound healing and regeneration. Periodontology 2000. 1993;1:69–79
  7. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontology 2000. 1999;19:40–58
  8. Coppock DL, Kopman C, Scandalis S, Gilleran S. Preferential gene expression in quiescent human lung fibroblasts. Cell Growth Differ. 1993;4:483–493
  9. Fisher LW, Termine JD, Young MF. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteogylcan II (Decorin) and several nonconnective tissue proteins in a variety of species. J. Biol. Chem. 1989;264:4571–4576
  10. Giannobile WV. Periodontal tissue engineering by growth factors. Bone. 1996;19:23S–37S
  11. Giannopoulou C, Ciamasoni G. Functional characteristics of gingival and periodontal ligament fibroblasts. J. Dent. Res. 1996;75:895–902
  12. Haase HR, Clarkson RW, Waters MJ, Bartold PM. Growth factor modulation of mitogenic responses and proteoglycan synthesis by human periodontal fibroblasts. J. Cell Physiol. 1998;174:353–361
  13. Hildebrand A, Romaris M, Rasumussen LM, Heinegard D, Twardzik DR, Border WA, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor-beta. Biochem. J. 1994;302:527–534
  14. Hocking AM, Shinomura T, McQuillan DJ. Leucine-rich repeat glycoproteins of the extracellular matrix. Matrix Biol. 1998;17:1–19
  15. Hou LT, Yaeger JA. Cloning and characterization of human gingival and periodontal ligament fibroblasts. J. Periodontol. 1993;64:1209–1218
  16. Iozzo RV, Murdoch AD. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB J. 1996;10:598–614
  17. Ivanovski S, Li H, Daly T, Bartold PM. An immunohistochemical study of matrix molecules associated with barrier membrane mediated periodontal wound healing. J. Periodontal Res. 2000;35:115–126
  18. Kahari VM, Larjava H, Uitto J. Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta1 upregulates biglycan (PGI) and versican (large fibroblast PG) but downregulates decorin (PGII) mRNA levels in human fibroblasts in culture. J. Biol. Chem. 1991;266:10608–10615
  19. Kuru L, Griffiths GS, Petrie A, Olsen I. Alkaline phosphatase activity is upregulated in regenerating human periodontal cells. J. Periodontal Res. 1999;34:123–127
  20. Laurell L, Gottlow J, Zybutz M, Persson R. Treatment of intrabony defects by different surgical procedures. A literature review. J. Periodontol. 1998;69:303–313
  21. Lynch SE, de Castilla GR, Williams RC, Kiritsy CP, Howell TH, Reddy MS, et al. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J. Periodontol. 1991;62:458–467
  22. Lynch SE, Nixon JC, Colvin RB, Antoniades HN. Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc. Natl. Acad. Sci. USA. 1987;84:7696–7700
  23. Lynch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, et al. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J. Clin. Periodontol. 1989;16:545–548
  24. Mariotti A, Cochran DL. Characterisation of fibroblasts derived from human periodontal ligament and gingiva. J. Periodontol. 1990;60:103–111
  25. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J. Periodontol. 1992;63:515–525
  26. Mauviel A, Santra M, Chen YQ, Uitto J, Iozzo RV. Transcriptional regulation of decorin expression. Induction by quiescence and repression by tumor necrosis factor-alpha. J. Biol. Chem. 1995;270:11692–11700
  27. Minabe M. A critical review of the biological rationale for guided tissue regeneration. J. Periodontol. 1991;62:171–179
  28. Naso MF, Zimmermann DR, Iozzo RV. Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. J. Biol. Chem. 1994;269:32999–33008
  29. Nietfeld JJ. Cytokines and proteoglycans. Experientia. 1993;49:456–469
  30. Nyman S, Gottlow J, Karring T, Lindhe J. The regenerative potential of the periodontal ligament: An experimental study in the monkey. J. Clin. Periodontol. 1982;9:257–265
  31. Nyman S, Karring T, Lindhe J, Planten S. Healing following implantation of periodontitis affected roots into gingival connective tissue. J. Clin. Periodontol. 1980;7:394–401
  32. Oates TW, Kalkwarf KL. Long-term prognosis following resectional and regenerative periodontal procedures. Curr. Opin. Periodontol. 1997;4:69–74
  33. Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J. Periodontol. 1993;64:142–148
  34. Rosselot G, Vasilatos-Younken R, Leach RM. Effect of growth hormone, insulin-like growth factor 1, basic fibroblast growth factor, and transforming growth factor beta on cell proliferation and proteoglycan synthesis by avian post embryonic growth plate chondrocytes. J. Bone Miner. Res. 1994;9:431–439
  35. Rowe DJ, Leung WW, Del Carlo DL. Osteoclast inhibition by factors from cells associated with regenerative tissue. J. Periodontol. 1996;67:414–421
  36. Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991;64:867–869
  37. Rutherford RB, Niekrash CE, Kennedy JE, Charette MF. Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys. J. Periodontal. Res. 1992;27:285–290
  38. Schonherr E, Jarvelainen HT, Sandell LJ, Wight TN. Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. J. Biol. Chem. 1991;266:17640–17647
  39. Somerman MJ, Archer SY, Imm GR, Foster RA. A comparative study of human periodontal ligament cells and gingival fibroblasts in vitro. J. Dent. Res. 1988;67:66–70
  40. Uldbjerg N, Danielson CC. A study of the interaction in vitro between type I collagen and a small dermatan sulphate proteoglycan. Biochem. J. 1988;251:643–648
  41. Vogel KG, Paulsson M, Heinegard D. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem. J. 1984;223:587–597
  42. Wakabayashi RC, Iha DK, Niu JJ, Johnson PW. Cytokine production by cells adherent to regenerative membranes. J. Periodontal Res. 1997;32:215–224
  43. Wakabayashi RC, Wong F, Richards DW, Johnson PW. Protease repertoires of cells adherent to membranes recovered after guided tissue regeneration. J. Periodontal Res. 1996;32:215–224
  44. Yang BL, Zhang Y, Cao L, Yang B. Cell adhesion and proliferation mediated through the G1 domain of versican. J. Cell Biochem. 1999;72:210–220
  45. Zhan Y, Cao L, Kiani CG, Yang BL, Yang BB. The G3 domain of versican inhibits mesenchymal chondrogenesis via epidermal growth factor-like motifs. J. Biol. Chem. 1998;273:33054–33063

PII: S0003-9969(01)00036-X

doi: 10.1016/S0003-9969(01)00036-X

Archives of Oral Biology
Volume 46, Issue 8 , Pages 679-688 , August 2001

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