Archives of Oral Biology
Volume 54, Issue 8 , Pages 737-742 , August 2009

Influence of gender on the metabolism of alcohols in human saliva in vitro

,Accepted 25 April 2009.

References 

  1. Ernstgård L, Shibata E, Johanson G. Uptake and disposition of inhaled methanol vapor in humans. Toxicol Sci. 2005;88:30–38
  2. Ernstgård L, Sjögren B, Warholm M, Johanson G. Sex differences in the toxicokinetics of inhaled solvent vapors in humans. 2. 2-Propanol. Toxicol Appl Pharmacol. 2003;193:158–167
  3. Gubala W, Zuba D. Gender differences in the pharmacokinetics of ethanol in saliva and blood after oral ingestion. Pol J Pharmacol. 2003;55:639–644
  4. Ferrari M, Negri S, Zadra P, Ghittori S, Imbriani M. Saliva as an analytical tool to measure occupational exposure to toluene. Int Arch Occup Environ Health. 2008;81:1021–1028
  5. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev. 1997;77:517–544
  6. Rezvani AH. 2-Propanol. In:  Thurman RG,  Kauffman FC editor. Alcohols and esters. 2nd ed.. Amsterdam: Elsevier; 1992;p. 31–37
  7. Salaspuro MP. Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Sci. 2003;40:183–208
  8. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7:599–612
  9. Jones AW. Measuring and reporting the concentration of acetaldehyde in human breath. Alcohol Alcohol. 1995;30:271–285
  10. Eriksson CJ. Measurement of acetaldehyde: what levels occur naturally and in response to alcohol?. Novartis Found Symp. 2007;285:247–255discussion 56–60
  11. Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, et al. Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8:292–293
  12. Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis. 1997;18:1739–1743
  13. National Board of Health and Welfare (Socialstyrelsen). Cancer incidence in Sweden; 2005. http://www.socialstyrelsen.se.
  14. Sreerama L, Hedge MW, Sladek NE. Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione S-transferases, and DT-diaphorase in the saliva of subjects who continually ingest large quantities of coffee or broccoli. Clin Cancer Res. 1995;1:1153–1163
  15. Dong YJ, Peng TK, Yin SJ. Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth. Alcohol. 1996;13:257–262
  16. Vondracek M, Xi Z, Larsson P, Baker V, Mace K, Pfeifer A, et al. Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis. 2001;22:481–488
  17. Lamster IB, Kaufman E, Grbic JT, Winston LJ, Singer RE. Beta-glucuronidase activity in saliva: relationship to clinical periodontal parameters. J Periodontol. 2003;74:353–359
  18. Takahama U, Hirota S, Nishioka T, Oniki T. Human salivary peroxidase-catalyzed oxidation of nitrite and nitration of salivary components 4-hydroxyphenylacetic acid and proteins. Arch Oral Biol. 2003;48:679–690
  19. Nishioka T, Maki K, Kimura M, Takahama U. Determination of salivary peroxidase activity in human mixed whole saliva. Arch Oral Biol. 2003;48:397–400
  20. Salaspuro V, Salaspuro M. Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int J Cancer. 2004;111:480–483
  21. Vahter M, Bellander T, Berglund M, Ernstgård L, Hanberg A, Högberg J, et al. Kemikalier och könskillnader 1. Stockholm: Karolinska Institutet; 2006. Report No. 3 (in Swedish).
  22. Helander A, Curvall M. Comparison of blood aldehyde dehydrogenase activities in moist snuff users, cigarette smokers and nontobacco users. Alcohol Clin Exp Res. 1991;15:1–6
  23. International Agency for Research on Cancer (IARC). Tobacco smoke and involuntary smoking. In: IARC monographs on evaluation of carcinogenic risk to humans. Lyon, France; 2004.
  24. Sarkola T, Iles MR, Kohlenberg-Mueller K, Eriksson CJ. Ethanol, acetaldehyde, acetate, and lactate levels after alcohol intake in white men and women: effect of 4-methylpyrazole. Alcohol Clin Exp Res. 2002;26:239–245
  25. Borras E, Coutelle C, Rosell A, Fernandez-Muixi F, Broch M, Crosas B, et al. Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology. 2000;31:984–989
  26. Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW, et al. Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res. 2001;25:502–507
  27. Hedberg JJ, Höög JO, Nilsson JA, Xi Z, Elfwing A, Grafström RC. Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa. Am J Pathol. 2000;157:1745–1755
  28. Hedberg JJ, Strömberg P, Höög JO. An attempt to transform class characteristics within the alcohol dehydrogenase family. FEBS Lett. 1998;436:67–70
  29. Ramchandani VA, Bosron WF, Li TK. Research advances in ethanol metabolism. Pathol Biol (Paris). 2001;49:676–682
  30. Nagler RM. Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring. Biogerontology. 2004;5:223–233
  31. Gupta A, Epstein JB, Sroussi H. Hyposalivation in elderly patients. J Can Dent Assoc. 2006;72:841–846

PII: S0003-9969(09)00100-9

doi: 10.1016/j.archoralbio.2009.04.011

Archives of Oral Biology
Volume 54, Issue 8 , Pages 737-742 , August 2009