Archives of Oral Biology
Volume 54, Issue 8 , Pages 764-771 , August 2009

Immunolocalization of matrix metalloproteinases-2 and -9 during apical periodontitis development

  • Mauro V. Corotti

      Affiliations

    • Laboratory of Biochemistry, Department of Biological Sciences, University of Sao Paulo, Bauru-SP, Brazil
    • These authors contributed equally to this study.
  • ,
  • Willian F. Zambuzzi

      Affiliations

    • Laboratory of Bioassays and Signal Transduction; Department of Biochemistry, Institute of Biology, University of Campinas, Campinas-SP, Brazil
    • These authors contributed equally to this study.
  • ,
  • Katiúcia B.S. Paiva

      Affiliations

    • Laboratory of Molecular Pathology, Department of Oral Pathology, Dental School, University of Sao Paulo, Sao Paulo-SP, Brazil
  • ,
  • Renato Menezes

      Affiliations

    • Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  • ,
  • Lidiane C. Pinto

      Affiliations

    • Laboratory of Pathology, Department of Stomatology, University of São Paulo, Bauru-SP, Brazil
  • ,
  • Vanessa S. Lara

      Affiliations

    • Laboratory of Pathology, Department of Stomatology, University of São Paulo, Bauru-SP, Brazil
  • ,
  • José M. Granjeiro

      Affiliations

    • Department of Cell and Molecular Biology, Institute of Biology, Fluminense Federal University, Niterói-RJ, Brazil
    • Cell and Molecular Biology Center (Nucell), University of São Paulo, São Paulo-SP, Brazil
    • Corresponding Author InformationCorresponding author. Department of Cell and Molecular Biology, Institute of Biology, Fluminense Federal University; Outeiro de São João Baptista, s/n; Campus do Valonguinho; Niteroi – RJ; Brazil; Zip Code: 24.020-150. Tel.: +55 21 2629 2324; fax: +55 21 3701 1617.

Received 22 January 2009 ,Revised 15 April 2009 ,Accepted 17 April 2009.

References 

  1. Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1965;20:340–349
  2. Nair PN. Pathogenesis of apical periodontitis and the causes of endodontic failures. Crit Rev Oral Biol Med. 2004;15:348–381
  3. Vernal R, Dezerega A, Dutzan N, Chaparro A, Leon R, Chandía S, et al. RANKL in human periapical granuloma: possible involvement in periapical bone destruction. Oral Dis. 2006;12:283–289
  4. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodontal Res. 1993;28:500–510
  5. Kreis T, Vale R. Matrix metalloproteinases. In:  Sternlicht MD,  Werb Z editor. Guidebook to the extracellular matrix, anchor, and adhesion proteins. 2nd ed.. San Francisco: Oxford University Press; 1999;p. 519–542
  6. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function and biochemistry. Circ Res. 2003;92:827–839
  7. Hannas AR, Pereira JC, Granjeiro JM, Tjäderhane L. The role of matrix metalloproteinases in the oral environment. Acta Odontol Scand. 2007;65:1–13
  8. Stashenko P, Yu SM, Wang CY. Kinetics of immune cell and bone resorptive responses to endodontic infections. J Endod. 1992;18:422–426
  9. Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004;10:311–318
  10. Shin SJ, Lee JI, Baek SH, Lim SS. Tissue levels of matrix metalloproteinases in pulps and periapical lesions. J Endod. 2002;28:313–315
  11. Carneiro E, Menezes R, Garlet GP, Garcia RB, Monteiro Bramante C, Figueira R, et al. Expression analysis of matrix metalloproteinase-9 in epithelialized and nonepithelialized apical periodontitis lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, in press, doi:10.1016/j.tripleo.2008.07.030.
  12. Leonardi R, Caltabiano R, Loreto C. Collagenase-3 (MMP-13) is expressed in periapical lesions: an immunohistochemical study. Int Endod J. 2005;38:297–301
  13. Lin SK, Kok SH, Kuo MY, Wang TJ, Yeh FT, Hsiao M, et al. Sequential expressions of MMP-1, TIMP-1, IL-6 and COX-2 genes in induced periapical lesions in rats. Eur J Oral Sci. 2002;110:246–253
  14. Accorsi-Mendonça T, Zambuzzi WF, da Silva Paiva KB, Pereira Lauris JR, Cestari TM, Taga R, et al. Expression of metalloproteinase 2 in the cell response to porous demineralized bovine bone matrix. J Mol Histol. 2005;36:311–316
  15. Menezes R, Bramante CM, Paiva KBS, Letra A, Carneiro E, Zambuzzi WF, et al. Receptor activator NFB-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:404–409
  16. Accorsi-Mendonça T, Paiva KB, Zambuzzi WF, Cestari TM, Lara VS, Taga R, et al. Expression of matrix metalloproteinases-2 and -9 and RECK during alveolar bone regeneration in rat. J Mol Histol. 2008;39:201–208
  17. Monteagudo C, Merino MJ, San-Juan J, Liotta LA, Stetler-Stevenson WG. Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue. Am J Pathol. 1990;136:585–592
  18. Ravindranath MH, Muthugounder S, Presser N, Viswanathan S. Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol. 2004;546:121–165
  19. Marton IJ, Kiss C. Protective and destructive immune reactions in apical periodontitis. Oral Microbiol Immunol. 2000;15:139–150
  20. Stashenko P, Wang CY, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 1994;78:494–502
  21. Chung L, Dinakarpandian D, Yohida N, Lauer-Fields JL, Fields B, Visse R, et al. Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J. 2004;23:3020–3030
  22. Pozo P, Valenzuela MA, Melej C, Zaldívar M, Puente J, Gamonal J. Longitudinal analysis of metalloproteinases, TIMPs and clinical parameters in gingival crevicular fluid from periodontitis-affected patients. J Periodontal Res. 2005;40:199–207
  23. Ingman T, Tervahartiala T, Ding Y, Tsesche H, Haerian A, Kinane DF, et al. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol. 1996;23:1127–1132
  24. Puente X, Sánchez L, Overall C, López-Otín C. Human and mouse proteases: a comparative genomic approach. Nat Rev Genet. 2003;4:544–556
  25. Shapiro SD, Senior RM. Matrix metalloproteinases. Matrix degradation and more. Am J Respir Cell Mol Biol. 1999;20:1100–1102
  26. McMillan SJ, Kearley J, Campbell JD, Zhu XW, Larbi KY, Shipley JM, et al. Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol. 2004;172:2586–2594
  27. Gonçalves LD, Oliveira G, Hurtado PA, Feitosa A, Takiya CM, Granjeiro JM, et al. Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies. J Periodontal Res. 2008;43:570–577
  28. Kuula H, Salo T, Pirilä E, Tuomainen AM, Jauhiainen M, Uitto VJ, et al. Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. Infect Immun. 2009;77:850–859
  29. Tjäderhane L, Hotakainen T, Kinnunen S, Ahonen M, Salo T. The effect of chemical inhibition of matrix metalloproteinases on the size of experimentally induced apical periodontitis. Int Endod J. 2007;40:282–289
  30. Tsubota M, Sasano Y, Takahashi I, Kagayama M, Shimauchi H. Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption. J Dent Res. 2002;81:673–678
  31. Kawashima N, Suzuki N, Yang G, Ohi C, Okuhara S, Nakano-Kawanishi H, et al. Kinetics of RANKL, RANK and OPG expressions in experimentally induced rat periapical lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:707–711
  32. Menezes R, Garlet TP, Letra A, Bramante CM, Campanelli AP, Figueira R, et al. Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. J Endod. 2008;34:932–938
  33. Gao Z, Mackenzie IC, Rittman BR, Korszun AK, Williams DM, Cruchley AT. Immunocytochemical examination of immune cells in periapical granulomata and odontogenic cysts. J Oral Pathol. 1988;17:84–90
  34. Patas S, Nakou M, Rontogianni D. Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study. Int Endod J. 2003;36:464–471
  35. Hernández M, Martínez B, Tejerina JM, Valenzuela MA, Gamonal J. MMP-13 and TIMP-1 determinations in progressive chronic periodontitis. J Clin Periodontol. 2007;34:729–735
  36. Ilgenli T, Vardar-Sengul S, Gürkan A, Sorsa T, Stackelberg S, Köse T, et al. Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. Oral Dis. 2006;12:573–579
  37. Zambuzzi WF, Yano CL, Cavagis ADM, Peppelenbosch MP, Granjeiro JM, Ferreira CV. Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2. Mol Cell Biochem. 2009;322:143–150
  38. Lin SK, Chiang CP, Hong CY, Lin CP, Lan WH, Hsieh CC, et al. Immunolocalization of interstitial collagenase (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in radicular cysts. J Oral Pathol Med. 1997;26:458–463

PII: S0003-9969(09)00122-8

doi: 10.1016/j.archoralbio.2009.04.013

Archives of Oral Biology
Volume 54, Issue 8 , Pages 764-771 , August 2009