Archives of Oral Biology
Volume 55, Issue 4 , Pages 288-293 , April 2010

OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin

  • Zhi-Feng Sheng

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
    • Dr. Sheng and Dr. Ye contributed equally to this work.
  • ,
  • Wei Ye

      Affiliations

    • Department of Spinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 107 Yanjiang West Rd, Guangdong 510120, PR China
    • Dr. Sheng and Dr. Ye contributed equally to this work.
  • ,
  • Jie Wang

      Affiliations

    • Department of General Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 107 Yanjiang West Rd, Guangdong 510120, PR China
  • ,
  • Chun-Hai Li

      Affiliations

    • Department of Spinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 107 Yanjiang West Rd, Guangdong 510120, PR China
  • ,
  • Jiang-Hua Liu

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
  • ,
  • Qing-Chun Liang

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
  • ,
  • Shan Li

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
  • ,
  • Kang Xu

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
    • Department of General Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 107 Yanjiang West Rd, Guangdong 510120, PR China
    • Corresponding Author InformationCorresponding author at: Department of General Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 107 Yanjiang West Rd, Guangdong 510120, PR China. Tel.: +86 20 81332800; fax: +86 20 81332800.
  • ,
  • Er-Yuan Liao

      Affiliations

    • Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +86 731 5361472; fax: +86 731 5361472.

,Accepted 18 February 2010.

References 

  1. Wise GE, Yao S, Zhang Q, Ren Y. Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption. Arch Oral Biol. 2002;47:247–254
  2. Ohazama A, Courtney JM, Sharpe PT. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. J Dent Res. 2004;83:241–244
  3. Suzuki T, Suda N, Ohyama K. Osteoclastogenesis during mouse tooth germ development is mediated by receptor activator of NFKappa-B ligand (RANKL). J Bone Miner Metab. 2004;22:185–191
  4. Heinrich J, Bsoul S, Barnes J, Woodruff K, Abboud S. CSF-1, RANKL and OPG regulate osteoclastogenesis during murine tooth eruption. Arch Oral Biol. 2005;50:897–908
  5. Lossdorfer S, Gotz W, Jager A. Immunohistochemical localization of receptor activator of nuclear factor kappaB (RANK) and its ligand (RANKL) in human deciduous teeth. Calcif Tissue Int. 2002;71:45–52
  6. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315–323
  7. Ida-Yonemochi H, Noda T, Shimokawa H, Saku T. Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas. J Oral Pathol Med. 2002;31:361–373
  8. Satokata I, Maas R. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet. 1994;6:348–356
  9. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, et al. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development. 1997;124:4811–4818
  10. Depew MJ, Lufkin T, Rubenstein JL. Specification of jaw subdivisions by Dlx genes. Science. 2002;298:381–385
  11. Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T, et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun. 1998;247:610–615
  12. Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H. Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res. 2004;83:920–925
  13. Wise GE, Yao S, Liu D. Injections of osteoprotegerin and PMA delay tooth eruption. Clin Anat. 2006;19:19–24
  14. Wu J, Wang XW, Takasaki M, Ohta A, Higuchi M, Ishimi Y. Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice. J Bone Miner Res. 2001;16:1829–1836
  15. Tommasini SM, Morgan TG, van der Meulen MCh, Jerpsen KJ. Genetic variation in structure–function relationships for the inbred mouse lumbar vertebral body. J Bone Miner Res. 2005;20:817–827
  16. Sheng ZF, Dai RC, Wu XP, Fang LN, Fan HJ, Liao EY. Regionally specific compensation for bone loss in the tibial trabeculae of estrogen-deficient rats. Acta Radiol. 2007;48:531–539
  17. Ritman EL. Micro-computed tomography-current status and developments. Annu Rev Biomed Eng. 2004;6:185–208
  18. Savage T, Bennett T, Huang YF, Kelly PL, Durant NE, Adams DJ, et al. Mandibular phenotype of p20C/EBPbeta transgenic mice: reduced alveolar bone mass and site-specific dentin dysplasia. Bone. 2006;39:552–564
  19. Stock SR, Ignatiev KI, Dahl T, Veis A, De Carlo F. Three-dimensional microarchitecture of the plates (primary, secondary, and carinar process) in the developing tooth of Lytechinus variegatus revealed by synchrotron X-ray absorption microtomography (microCT). J Struct Biol. 2003;144:282–300
  20. Spoor CF, Zonneveld FW, Macho GA. Linear measurements of cortical bone and dental enamel by computed tomography: applications and problems. Am J Phys Anthropol. 1993;91:469–484
  21. Nielsen RB, Alyassin AM, Peters DD, Carnes DL, Lancaster J. Microcomputed tomography: an advanced system for detailed endodontic research. J Endodon. 1995;21:561–568
  22. Tanaka E, Sano R, Kawai N, Langenbach GE, Brugman P, Tanne K, et al. Effect of food consistency on the degree of mineralization in the rat mandible. Ann Biomed Eng. 2007;35:1617–1621
  23. Balto K, Müller R, Carrington DC, Dobeck J, Stashenko P. Quantification of periapical bone destruction in mice by micro-computed tomography. J Dent Res. 2000;79:35–40
  24. Udagawa N, Takahashi N, Yasuda H, Mizuno A, Itoh K, Ueno Y, et al. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology. 2000;141:3478–3484
  25. Sasaki T. Differentiation and functions of osteoclasts and odontoclasts in mineralized tissue resorption. Microsc Res Technol. 2003;61:483–495
  26. Cielinski MJ, Jolie M, Wise GE, Marks SC. The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat. Connect Tissue Res. 1995;32:165–169
  27. Wise GE, Grier RL, Lumpkin SJ, Zhang Q. Effects of dexamethasone on tooth eruption in rats: differences in incisor and molar eruption. Clin Anat. 2001;14:204–209
  28. Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, et al. Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med. 1999;190:293–298
  29. Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, et al. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med. 2000;191:275–286

PII: S0003-9969(10)00047-6

doi: 10.1016/j.archoralbio.2010.02.007

Archives of Oral Biology
Volume 55, Issue 4 , Pages 288-293 , April 2010