Archives of Oral Biology
Volume 55, Issue 7 , Pages 502-508 , July 2010

Blockade of sympathetic β-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model

  • Yuka Okada

      Affiliations

    • Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Kanagawa, Japan
  • ,
  • Nobushiro Hamada

      Affiliations

    • Department of Infection Control, Division of Microbiology, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, 238-8580 Kanagawa, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 468 22 8867; fax: +81 468 22 8867.
  • ,
  • Yul Kim

      Affiliations

    • Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Kanagawa, Japan
  • ,
  • Yusuke Takahashi

      Affiliations

    • Department of Infection Control, Division of Microbiology, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, 238-8580 Kanagawa, Japan
  • ,
  • Kenichi Sasaguri

      Affiliations

    • Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Kanagawa, Japan
  • ,
  • Satoru Ozono

      Affiliations

    • Institute for Frontier Oral Science, Kanagawa Dental College, Kanagawa, Japan
  • ,
  • Sadao Sato

      Affiliations

    • Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Kanagawa, Japan

,Accepted 6 April 2010.

References 

  1. Breivik T, Thrane PS, Gjermo P, Opstad PK. Glucocorticoid receptor antagonist RU 486 treatment reduces periodontitis in Fischer 344 rats. J Periodontal Res. 2000;35(5):285–290
  2. Breivik T, Gundersen Y, Fonnum F, Vaagenes P, Opstad PK. Chronic glycine treatment inhibits ligature-induced periodontal disease in Wistar rats. J Periodontal Res. 2005;40(1):43–47
  3. Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev. 1998;62(4):1244–1263
  4. Genco RJ. Current view of risk factors for periodontal diseases. J Periodontol. 1996;67(10):1041–1049
  5. Singh IJ, Herskovits MS, Chiego DJ, Klein RM. Modulation of osteoblastic activity by sensory and autonomic innervation of bone. Prog Clin Biol Res. 1982;101:535–551
  6. Haug SR, Heyeraas KJ. Modulation of dental inflammation by the sympathetic nervous system. J Dent Res. 2006;85(6):488–495
  7. Breivik T, Thrane PS, Murison R, Gjermo P. Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci. 1996;104(4):327–334
  8. Ladizesky M, Lama MA, Roldán EJ, Cutrera RA, Boggio V, Giglio MJ, et al. Effect of unilateral superior cervical ganglionectomy on mandibular bone in rats. Neuro Endocrinol Lett. 2003;24(5):314–320
  9. Ladizesky MG, Cutrera RA, Boggio V, Mautalen C, Cardinali DP. Effect of unilateral superior cervical ganglionectomy on bone mineral content and density of rat's mandible. J Auton Nerv Syst. 2000;78(2–3):113–116
  10. Togari A. Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells. Microsc Res Technol. 2002;58(2):77–84
  11. Hall NR, Goldstein AL. Endocrine regulation of host immunity. In:  Fenichel RL,  Chirogos MA editor. Immune modulation agents and their mechanisms. New York: Marcel Dekker; 1984;p. 533–563
  12. Singh VK, Warren RP, White RD, Leu SJC. Corticotropin-releasing factor induced stimulation of immune functions. Ann NY Acad Sci. 1990;594:416–419
  13. Mantyh PW. Substance P and the inflammatory and immune response. Ann NY Acad Sci. 1991;632:263–271
  14. Bletsa A, Heyeraas KJ, Haug SR, Berggreen E. IL-1 alpha and TNF-alpha expression in rat periapical lesions and dental pulp after unilateral sympathectomy. Neuroimmunomodulation. 2004;11(6):376–384
  15. Genco RJ, Ho AW, Grossi SG, Dunford RG, Tedesco LA. Relationship of stress, distress and inadequate coping behaviors to periodontal disease. J Periodontol. 1999;70(7):711–723
  16. Pierroz DD, Bouxsein ML, Rizzoli R, Ferrari SL. Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice. Bone. 2006;39(2):260–267
  17. Reid IR, Lucas J, Wattie D, Horne A, Bolland M, Gamble GD, et al Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab. 2005;90(9):5212–5216
  18. Valdivia LF, Centurión D, Perusquía M, Arulmani U, Saxena PR, Villalón CM. Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats. Life Sci. 2004;74(26):3223–3234
  19. Nakajima K, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Umemoto T, et al. Restraint stress enhances alveolar bone loss in an experimental rat model. J Periodontal Res. 2006;41(6):527–534
  20. Hamada N, Watanabe K, Tahara T, Nakazawa K, Ishida I, Shibata Y, et al The r40-kDa outer membrane protein human monoclonal antibody protects against Porphyromonas gingivalis-induced bone loss in rats. J Periodontol. 2007;78(5):933–939
  21. De Luigi A, Terreni L, Sironi M, De Simoni MG. The sympathetic nervous system tonically inhibits peripheral interleukin-1beta and interleukin-6 induction by central lipopolysaccharide. Neuroscience. 1998;83(4):1245–1250
  22. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, et al Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002;111(3):305–317
  23. Togari A, Arai M. Pharmacological topics of bone metabolism: the physiological function of the sympathetic nervous system in modulating bone resorption. J Pharmacol Sci. 2008;106(4):542–546
  24. Kim Y, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Onozuka M, et al. Cervical sympathectomy causes alveolar bone loss in an experimental rat model. J Periodont Res. 2009;44(6):695–703
  25. O’Connell AC, Van Wuyckhuyse BC, Pearson SK, Bowen WH. The effect of propranolol on salivary gland function and dental caries development in young and aged rats. Arch Oral Biol. 1993;38(10):853–861
  26. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, et al Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005;434(7032):514–520
  27. Turker S, Karatosun V, Gunal I. Beta-blockers increase bone mineral density. Clin Orthop Relat Res. 2006;443:73–74
  28. Dimitrijević M, Rauški A, Radojević K, Kosec D, Stanojević S, Pilipović I, et al. β-Adrenoceptor blockade ameliorates the clinical course of experimental allergic encephalomyelitis and diminishes its aggravation in adrenalectomized rats. Eur J Pharmacol. 2007;577(1–3):170–182
  29. Bai YD, Yang FS, Xuan K, Bai YX, Wu BL. Inhibition of RANK/RANKL signal transduction pathway: a promising approach for osteoporosis treatment. Med Hypotheses. 2008;71(2):256–258
  30. Cohen S, Williamson GM. Stress and infectious disease in humans. Psychol Bull. 1991;109(1):5–24
  31. Sheridan JF, Dobbs C, Brown D, Zwilling B. Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection. Clin Microbiol Rev. 1994;7(2):200–212
  32. Blalock JE. The syntax of immune-neuroendocrine communication. Immunol Today. 1994;15(11):504–511

PII: S0003-9969(10)00101-9

doi: 10.1016/j.archoralbio.2010.04.002

Archives of Oral Biology
Volume 55, Issue 7 , Pages 502-508 , July 2010