Archives of Oral Biology
Volume 55, Issue 7 , Pages 509-514 , July 2010

Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric oxide formation after oral Porphyromonas gingivalis inoculation in mice

  • Nemec Ana

      Affiliations

    • Veterinary Faculty Small Animal Clinic, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia
    • Corresponding Author InformationCorresponding author. Current address: Dentistry & Oral Surgery Service, Veterinary Medical Teaching Hospital, University of California, Davis, One Shields Avenue, Davis, CA 95616-8747, USA. Tel.: +1 530 752 2470; fax: +1 530 752 9620.
  • ,
  • Pavlica Zlatko

      Affiliations

    • Veterinary Faculty Small Animal Clinic, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia
  • ,
  • Petelin Milan

      Affiliations

    • Department for Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana, Hrvatski trg 1, 1000 Ljubljana, Slovenia
  • ,
  • Crossley David A.

      Affiliations

    • Veterinary Faculty Small Animal Clinic, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia
  • ,
  • Šentjurc Marjeta

      Affiliations

    • Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
  • ,
  • Jerin Aleš

      Affiliations

    • University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Njegoševa 4, Ljubljana, Slovenia
  • ,
  • Eržen Damijan

      Affiliations

    • University Clinic of Respiratory and Allergic Diseases Golnik, 4240 Golnik, Slovenia
  • ,
  • Zdovc Irena

      Affiliations

    • Institute of Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia
  • ,
  • Hitti Tina

      Affiliations

    • Veterinary Faculty Small Animal Clinic, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia
  • ,
  • Skalerič Uroš

      Affiliations

    • Department for Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana, Hrvatski trg 1, 1000 Ljubljana, Slovenia

,Accepted 7 April 2010.

References 

  1. Di Paola R, Marzocco S, Mazzon E, Dattola F, Rotondo F, Britti D, et al. Effect of aminoguanidine in ligature-induced periodontitis in rats. J Dent Res. 2004;83(4):343–348
  2. Thippeswamy T, McKay JS, Quinn JP, Morris R. Nitric oxide, a biological double-faced janus—is this good or bad?. Histol Histopathol. 2006;21(4):445–458
  3. Tinker AC, Wallace AV. Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases?. Curr Top Med Chem. 2006;6:77–92
  4. Paquette DW, Rosenberg A, Lohinai Z, Southan GJ, Williams RC, Offenbacher S, et al. Inhibition of experimental gingivitis in beagle dogs with topical mercaptoalkylguanidines. J Periodontol. 2006;77(3):385–391
  5. Skalerič U, Gašpirc B, McCartney-Francis N, Masera A, Wahl SM. Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease. Infect Immun. 2006;74(12):7010–7013
  6. Leitao RF, Ribeiro RA, Chaves HV, Rocha FA, Lima V, Brito GA. Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats. J Periodontol. 2005;76(6):956–963
  7. Kim SJ, Choi EY, Cho YJ, Lee JY, Choi JI, Choi IS. Surface-associated material from Porphyromonas gingivalis stimulates the release of nitric oxide by inducing expression of inducible nitric oxide synthase. Microbes Infect. 2006;8(2):470–477
  8. Nemec A, Pavlica Z, Crossley DA, Šentjurc M, Jerin A, Eržen D, et al. Chronic ingestion of Porphyromonas gingivalis induces systemic nitric oxide response in mice. Oral Microbiol Immunol. 2009;24:204–210
  9. Hardham J, Reed M, Wong J, King K, Laurinat B, Sfintescu C, et al. Evaluation of a monovalent companion animal periodontal disease vaccine in an experimental mouse periodontitis model. Vaccine. 2005;23(24):3148–3156
  10. Dambrova M, Kirjanova O, Baumane L, Liepinsh E, Zvejniece L, Muceniece R, et al. EPR investigation of in vivo inhibitory effect of guanidine compounds on nitric oxide production in rat tissues. J Physiol Pharmacol. 2003;54(3):339–347
  11. Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997;272(8):4959–4963
  12. McCluskie K, Birrell MA, Wong S, Belvisi MG. Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: possible role in lung neutrophilia. J Pharmacol Exp Ther. 2004;311(2):625–633
  13. Nemec A, Pavlica Z, Crossley DA, Zdovc I, Eržen D, Petelin M, et al. Single oral inoculation with Escherichia coli (ATCC 25922) stimulates generalised production of nitric oxide in mice. Acta Vet Hung. 2009;57(1):127–138
  14. Berliner LJ, Fujii H. In vivo spin trapping of nitric oxide. Antioxid Redox Signal. 2004;6(3):649–656
  15. Nemec A, Pavlica Z, Šentjurc M, Crossley DA, Jerin A, Eržen D, et al. Single gavage with Porphyromonas gingivalis reduces acute systemic nitric oxide response in mice. Oral Microbiol Immunol. 2008;23:435–439
  16. Suzuki Y, Fujii S, Numagami Y, Tominaga T, Yoshimoto T, Yoshimura T. In vivo nitric oxide detection in the septic rat brain by electron paramagnetic resonance. Free Radic Res. 1998;28(3):293–299
  17. Tsikas D. Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Radic Res. 2005;39(8):797–815
  18. Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol. 1999;70(7):793–802
  19. Scannapieco FA. Systemic effects of periodontal diseases. Dent Clin North Am. 2005;49(3):533–550
  20. Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev. 1998;62(4):1244–1263
  21. Price S, Mitchell JA, Anning PB, Evans TW. Type II nitric oxide synthase activity is cardio-protective in experimental sepsis. Eur J Pharmacol. 2003;472(1–2):111–118
  22. Kubes P. Inducible nitric oxide synthase: a little bit of good in all of us. Gut. 2000;47(1):6–9
  23. Moroz LL, Norby SW, Cruz L, Sweedler JV, Gillette R, Clarkson RB. Non-enzymatic production of nitric oxide (NO) from NO synthase inhibitors. Biochem Biophys Res Commun. 1998;253(3):571–576
  24. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J. 2001;357(Pt 3):593–615
  25. Hayashi Y, Abe M, Murai A, Shimizu N, Okamoto I, Katsuragi T, et al. Comparison of effects of nitric oxide synthase (NOS) inhibitors on plasma nitrite/nitrate levels and tissue NOS activity in septic organs. Microbiol Immunol. 2005;49(2):139–147
  26. Persichini T, Cantoni O, Suzuki H, Colasanti M. Cross-talk between constitutive and inducible NO synthase: an update. Antioxid Redox Signal. 2006;8(5–6):949–954
  27. Parmentier S, Bohme GA, Lerouet D, Damour D, Stutzmann JM, Margaill I, et al. Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br J Pharmacol. 1999;127(2):546–552
  28. Johannes T, Mik EG, Klingel K, Goedhart PT, Zanke C, Nohe B, et al. Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetised rats. Clin Exp Pharmacol Physiol. 2009;36(9):870–879
  29. Ng ES, Cheng ZJ, Ellis A, Ding H, Jiang Y, Li Y, et al. Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin. Eur J Pharmacol. 2007;560(2–3):183–192
  30. Suliburk JW, Helmer KS, Kennison SD, Mercer DW, Robinson EK. Time-dependent aggravation or attenuation of lipopolysaccharide-induced gastric injury by nitric oxide synthase inhibition. J Surg Res. 2005;129(2):265–271
  31. Inada H, Ono H, Minami J, Ishimitsu T, Matsuoka H. Nipradilol prevents l-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. Hypertens Res. 2002;25(3):433–440
  32. Pechanova O, Bernatova I, Babal P. Structural alterations in the heart after long-term l-NAME and d-NAME treatment. Gen Physiol Biophys. 1999;18(Suppl. 1):6–9
  33. Chakravortty D, Hensel M. Inducible nitric oxide synthase and control of intracellular bacterial pathogens. Microbes Infect. 2003;5(7):621–627
  34. Cherayil BJ, Antos D. Inducible nitric oxide synthase and Salmonella infection. Microbes Infect. 2001;3(9):771–776
  35. Eisenstein TK. Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule. Microbes Infect. 2001;3(14–15):1223–1231
  36. Gyurko R, Boustany G, Huang PL, Kantarci A, Van Dyke TE, Genco CA, et al. Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis. Infect Immun. 2003;71(9):4917–4924

PII: S0003-9969(10)00102-0

doi: 10.1016/j.archoralbio.2010.04.003

Archives of Oral Biology
Volume 55, Issue 7 , Pages 509-514 , July 2010