Archives of Oral Biology
Volume 55, Issue 7 , Pages 523-529 , July 2010

Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats

  • Marilene Issa Fernandes

      Affiliations

    • Periodontology, Faculty of Dentistry, Federal University of Rio Grande do SulPorto Alegre, Brazil
    • ,
  • Eduardo José Gaio

      Affiliations

    • Post-Graduate Program in Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Sul, Brazil
    • Corresponding Author InformationCorresponding author at: Av. Montenegro, 160/701 – CEP: 90460-160, Porto Alegre, RS, Brazil. Tel.: +55 51 32330434; fax: +55 51 32330434.
    • ,
  • Cristiano Susin

      Affiliations

    • Departments of Periodontics & Oral Biology, Medical College of Georgia School of Dentistry, Augusta, GA, USA
    • ,
  • Cassiano Kuchenbecker Rösing

      Affiliations

    • Periodontology, Faculty of Dentistry, Federal University of Rio Grande do SulPorto Alegre, Brazil
    • ,
  • Rui Vicente Oppermann

      Affiliations

    • Periodontology, Faculty of Dentistry, Federal University of Rio Grande do SulPorto Alegre, Brazil
    • ,
  • Pantelis Varvaki Rados

      Affiliations

    • Oral Pathology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

,Accepted 10 May 2010.

References 

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  2. Shimizu Y, Kataoka M, Seto H, Kido J, Nagata T. Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis. J Periodontol. 2002;73:861–867
  3. Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol. 1999;70:63–67
  4. Barak S, Engelberg IS, Hiss J. Gingival hyperplasia caused by nifedipine. Histopathologic findings. J Periodontol. 1987;58:639–642
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  10. Spolidorio LC, Spolidorio DM, Nassar PO, Nassar CA, Holzhausen M, Almeida OP. Influence of age on combined effects of cyclosporin and nifedipine on rat alveolar bone. J Periodontol. 2004;75:268–272
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  12. Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, et al. The American Journal of Cardiology and Journal of Periodontology Editors’ Consensus: Periodontitis and Atherosclerotic Cardiovascular Disease (diamond). J Periodontol. 2009;80:1021–1032
  13. Cavagni J, Soletti AC, Gaio EJ, Rosing CK. The effect of dexamethasone in the pathogenesis of ligature-induced periodontal disease in Wistar rats. Pesqui Odontol Bras. 2005;19:290–294
  14. Fernandes MI, Gaio EJ, Oppermann RV, Rados PV, Rosing CK. Comparison of histometric and morphometric analyses of bone height in ligature-induced periodontitis in rats. Braz Oral Res. 2007;21:216–221
  15. Simch RP, Gaio EJ, Rosing CK. Effect of body weight in the pathogenesis of ligature-induced periodontal disease in Wistar rats. Acta Odontol Scand. 2008;66:130–134
  16. Verzeletti GN, Gaio EJ, Rosing CK. Effect of methotrexate on alveolar bone loss in experimental periodontitis in Wistar rats. Acta Odontol Scand. 2007;65:348–351
  17. Morisaki I, Kato K, Loyola-Rodriguez JP, Nagata T, Ishida H. Nifedipine-induced gingival overgrowth in the presence or absence of gingival inflammation in rats. J Periodontal Res. 1993;28:396–403
  18. Bullon P, Machuca G, Martinez Sahuquillo A, Rojas J, Lacalle JR, Rios JV, et al. Clinical assessment of gingival size among patients treated with diltiazem. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:300–304
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  20. Nishikawa S, Nagata T, Morisaki I, Oka T, Ishida H. Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model. J Periodontol. 1996;67:463–471
  21. Kataoka M, Shimizu Y, Kunikiyo K, Asahara Y, Azuma H, Sawa T, et al. Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts. J Periodontol. 2001;72:1078–1083
  22. Ishida H, Kondoh T, Kataoka M, Nishikawa S, Nakagawa T, Morisaki I, et al. Factors influencing nifedipine-induced gingival overgrowth in rats. J Periodontol. 1995;66:345–350
  23. Spolidorio LC, Spolidorio DM, Benatti C, Sampaio JE, Almeida OP. Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. J Periodontal Res. 2003;38:375–379
  24. Chiu HC, Fu E, Chiang CY, Liu D. Does nifedipine aggravate cyclosporin-induced gingival overgrowth? An experiment in rats. J Periodontol. 2001;72:532–537
  25. Morisaki I, Fukui N, Fujimori Y, Murakami J, Daikoku H, Amano A. Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats. J Periodontol. 2000;71:438–443
  26. Ozaki Y, Kunimatsu K, Tajiri K, Hara Y, Kato Y, Aoki Y, et al. Role of medullasin in nifedipine-induced gingival overgrowth in rats. Arch Oral Biol. 1998;43:801–810
  27. Spoildorio LC, Spolidorio DM, Neves KA, Gonzaga HF, Almeida OP. Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats. J Periodontal Res. 2002;37:192–195

PII: S0003-9969(10)00121-4

doi: 10.1016/j.archoralbio.2010.05.003

Archives of Oral Biology
Volume 55, Issue 7 , Pages 523-529 , July 2010

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